This course will cover the theory and experimental implementation of parallel microscale experimentation used in the development of chemical reaction processes with a focus on organic chemistry transformations. Coverage includes the precepts behind design of experiment as well as errors commonly encountered in parallel microscale experimentation. Basic machine learning principles will be covered with the goal of selecting appropriate substrate/catalyst selection and generating predictive models using RDKit and Python. There is a laboratory component which may extend outside of listed class hours.

This course will provide an introduction to methods and applications of contemporary biochemical techniques and instrumentation used for analysis of biomolecules, including proteins, DNA/RNA and metabolites. Topics covered will include chromatographic and electrophoresis, mass spectrometry, fluorescence microscopy for the detection, characterization and structural analysis of proteins, antibodies and nucleic acids. The focus of the course will be applications in bioanalysis, biopharmaceuticals and biotechnology.

Natural products such as tetrodotoxin, kainic acid ,and morphine have played a crucial role in the development of neuroscience. Using selected chemical syntheses as a framework, I will provide an introduction to neuroscience for chemists blended with a course in synthetic design. The structure function and synthesis of the following molecules will be analyzed: tetrodotoxin, saxitoxin, kainic acid, nicotine epibatidine, coniine, histrionicotoxin, strychnine, chrysanthemic acid, morphine, salvinorin A, THC, lysergic acid, huperzin A. galanthamine, cocaine, reserpine, capsaicin. resiniferatoxin, retinal, carotene menthol, camphor and the prostaglandins. The structure and function of important ion channels, GPCRs transporters, and enzymes and their ligands will be discussed using PyMol files.
Goals: The goal of this course is to get as many synthetic chemists excited about neuroscience as possible (and a few neuroscientists stoked about synthesis). The importance of structural and pharmacological databases (PDB and IUPHAR, respectively)m and the usefulness of the Reaxys database (and SciFinder) for synthetic planning will be demonstrated.
Requirements: A familiarity with synthetic organic chemistry and (named) chemical reactions a mastery of the Nernst equation and a willingness to learn more about one of the greatest if not the greatest scientific challenges of our times: to figure out how the human brain works.

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development.
Med Chem II builds on the material in Med Chem I and focuses on specific drug targets such as enzyme, G-protein coupled receptors, channels, nucleic acids and protein-protein interactions. Additionally, therapeutics area specific medicinal chemistry and drug discovery applications will be covered including anti-cancer agents, anti-infectives (antibiotics and anti-virals), and therapeutics to treat psychiatric and neurodegenerative disorders. This course is geared to upper level undergraduate students in chemistry or biochemistry and graduate students. Completion of Session I is a prerequisite.

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development. Topics include the drug discovery process, drug targets (GRCR?s, enzymes, channels etc.), physical chemistry of molecular interactions between drug and target, drug design, methods for hit and lead identification, lead optimization, chemical biology, natural products chemistry and combinatorial and diversity oriented synthesis. This course is geared to upper level undergraduate students in chemistry or biochemistry, and first year chemistry graduate students. A strong understanding of organic chemistry is required.

The course will focus on Essential Practical NMR for Chemistry. Topics will include structure elucidation with 1D and 2D NMR spectra, how to obtain high quality NMR spectra on spectrometers, data processing with NMR software such as MNova and TOPSPIN, multi-nuclei NMR including 31P, 19F, 11B, 15N and 2H etc., dynamic and kinetic NMR, and some techniques to provide high resolution 2D NMR spectra.

A Mass Spectrometry introductory course describing MS history, key ionization methods, mass analyzers, and MS methods for structure elucidation. The successful participant will be able to:
Extract key information from stable isotope distribution patterns.
Interpret key mass spectral fragment/product ions from a spectrum when acquired.
Understand the differences between the major ionization sources.
Understand the differences between the major mass analyzers.
Determine reasonable ionization methods and analyzers for a sample or project.

This course, for graduate students, encompasses topics in fundamental and applied photochemistry and photophysics from the fields of organic chemistry and chemical biology. Key topics and concepts will include basic photophysics, interactions of light with matter, UV-Vis absorption and emission spectroscopy, energy transfer, kinetics/dynamics, Jablonski diagrams, electron transfer, organic photochemistry, and applications in organic chemistry and chemical biology. These topics and concepts will be covered in the context of frontier applications including synthetic chemistry organic photochemistry, molecular imaging, and optogenetic tools among others.

This course examines the structure and organization of the chemical literature in the field of organic chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Search skills are taught using a combination of lecture and laboratory activities, and students learn advanced text-based search techniques, complex substructure and reaction search techniques, methods of using the literature for retrosynthetic analysis, and methods of retrieving property information and profiling substances by their properties. In addition to search skills, the students are exposed to strategies for choosing a publication venue; the use and limitations of citation information when evaluating authors, institutions, and journals; and the basic principles behind peer review. The semester closes with a brief introduction to personal data management and an in-depth discussion of the ethics surrounding scientific communication.
The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in organic chemistry research.

This course examines the structure and organization of the chemical literature in the field of inorganic and materials chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Search skills are taught using a combination of lecture and laboratory activities, and students learn advanced text-based search techniques; advanced substructure and composition searches, with an emphasis on organometallic and inorganic substances and crystal structure data; reaction search techniques, focusing on catalyzed reactions; and methods of retrieving property information and profiling substances and materials by their properties. In addition to search skills, the students are exposed to strategies for choosing a publication venue; the use and limitations of citation information when evaluating authors, institutions, and journals; and the basic principles behind peer review. The semester closes with a brief introduction to personal data management and an in-depth discussion of the ethics surrounding scientific communication.
The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in organometallic, inorganic, or materials chemistry.