Event

Abstract

- Covalent protein modification chemistries have become an essential component to a wide array of fields ranging from drug discovery and chemical biology to materials chemistry.  As a result,  the development of new ligation chemistries with enhanced sophistication and new capabilities serve to not only enable access to protein conjugates with new functional properties but can also provide unique lenses through which to probe biological structure and processes directly in a native environment.  This seminar will discuss recent efforts by our group to develop unique chemical transformations that covalently modify biological matter via unusual or underexplored mechanistic pathways as well as their application in the study of complex biological systems. 

Research Description

Chemical transformations that create non-natural covalent bonds on biomolecules are truly empowering as they enable new approaches to the study of biological processes, drug discovery and therapeutic design, as well as the design of functional materials.  However, reactions that modify biomolecules must meet a stringent set of requirements in order to function in complex biological environments and thus their development presents a unique and exciting chemical challenge. 

https://cbc.arizona.edu/person/michael-taylor

Host Prof. Dave Chenoweth