Event

Abstract

This presentation will describe a series of cationic reagents that enable rapid arylation of cysteine under mild conditions compatible with proteins and peptides. These uncatalyzed reactions can proceed with exceptionally high rate constants in pH 7.0 aqueous buffer at 25 °C. Such reactions allow for stoichiometric bioconjugation of micromolar cysteine within minutes or even seconds. Even though the arylation is extremely fast, the chemistry exhibits excellent selectivity, thus furnishing functionalized peptides and proteins with both high conversion and purity. 

Biography

Dr. Goldberg is an Assistant Professor in the Chemistry Department at Colgate University. After completing his undergraduate degree at Dartmouth University, he received a Ph.D. at the University of Pennsylvania and conducted postdoctoral research at MIT.

Dr. Goldberg’s research focuses on synthesis and application of chemical probes to study complex biological systems. 

Inquiries: nguyeny@sas.upenn.edu

Location: Carolyn Hoff Lynch Lecture Hall