Event

Remote via Zoom:

https://upenn.zoom.us/j/97682459971

Meeting ID: 976 8245 9971

Dr. Amelie Heuer-Jungemann

Max Planck Institute of Biochemistry

“DNA origami – from nanoagents and nanosensors to artificial fossils”

DNA nanotechnology allows for the bottom-up synthesis of nanometer-sized objects with high precision and selective addressability due to the programmable hybridization of complementary DNA strands via Watson-Crick base pairing. The introduction of DNA origami in 2006 has resulted in a plethora of objects of different shapes and sizes, many of which have been site-specifically modified with a variety of functional moieties such as proteins or nanoparticles. In this talk, I will take you on a journey from building gold nanoparticle-decorated DNA crystals to biomedical nanoagents. I will demonstrate how DNA origami can be used to decipher complex ligand-receptor interactions, and how fossils inspired us to create super-stable DNA origami nanostructures through biomimetic chemistry.