Event

Remote option available:

https://upenn.zoom.us/j/97682459971

Meeting ID: 976 8245 9971

Dr. Dirk Trauner

New York University

“Controlling the Fate and Function of Proteins with Proximity Photopharmacology”

Abstract: Photopharmacology endeavors to control biological function with synthetic photoswitches that can be attached covalently or non-covalently to their targets - or nearby. I will discuss potential applications of photopharmacology in biology and medicine, in particular with respect to controlling signal transduction and targeted protein degradation. I will make a case that "Proximity Photopharmacology" is a particularly effective strategy to control the fate and function of proteins, with an emphasis on applications in neuroscience.

Dirk Trauner was born and raised in Linz, Austria, studied biology and chemistry at the University of Vienna, and received his Master’s degree in chemistry from the Free University, Berlin. He then pursued a Ph.D. in chemistry under the direction of Prof. Johann Mulzer, with whom he moved to the University of Frankfurt and then back to Vienna. Subsequently, he became a postdoctoral fellow with Prof. Samuel J. Danishefsky at the Memorial Sloan-Kettering Cancer Center. After two years in New York City, Dr. Trauner joined the Department of Chemistry at the University of California, Berkeley, where he rose through the ranks to become an Associate Professor of chemistry and a member of the Lawrence Berkeley National Laboratory. In the summer of 2008, he moved to the University of Munich, where he served as a Professor of Chemical Biology and Chemical Genetics. In March of 2017 he returned to the U.S. to become the Janice Cutler Chair of Chemistry at New York University. In the Spring of 2021, he is slated to become a PIK Professor at UPenn with an appointment in SPATT and in Chemistry. He is a member of the Leopoldina Academy of Sciences and the Austrian Academia of Sciences, and a recipient of the Otto Bayer Award, the Emil Fischer Medal, an ACS Cope Scholar Award, and a Sloan Fellowship. The broad objective of Prof. Trauner’s research is to demonstrate the awesome power of chemical synthesis and to use it toward the precision control of biological pathways.