CHEM7510 - Chemical Biology of Drug Discovery

This course will introduce topics in Chemical Biology and pharmacology and how they are applied for both basic and translational research. The course is focused on how basic science technology can be applied to discover a drug. The main components include: (1) selection of a disease with a focus on rare diseases (2) selection of a drug target, and (3) determining whether or not a small molecule interaction with that target can be expected to produce a therapeutic response. Key concepts of small molecule drug discovery are discussed throughout the course. Key technologies such as chemical proteomics and targeted degradation are covered. The advantages and disadvantages of therapeutic small molecules versus biologics will be discussed.